Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria

Atsushi Takahashi, Kenji Onodera, Hisashi Shinoda, Hideaki Mayanagi

研究成果: Article査読

39 被引用数 (Scopus)

抄録

The effects of phenytoin and its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), on bone resorption of neonatal mouse calvaria were examined in vitro. Both phenytoin and HPPH induced significant bone resorption as compared to the controls after 72 h in culture. This effect may be the cause of phenytoin-induced bone loss in vivo.

本文言語English
ページ(範囲)82-84
ページ数3
ジャーナルJapanese Journal of Pharmacology
82
1
DOI
出版ステータスPublished - 2000

ASJC Scopus subject areas

  • 薬理学

フィンガープリント

「Phenytoin and its metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin, show bone resorption in cultured neonatal mouse calvaria」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

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