Phenotyping CYP3A4 and CYP3A5 in pediatrie populations by liquid chromatography/tandem mass spectrometry

Anita Tilve, Santosh Tilve, Naiyu Zheng, Ye Tian, Tomoyuki Oe, Peter C. Adamson, Jeffrey L. Galinkin, Ian A. Blair

研究成果: Paper査読

抄録

The CYP3A4 and CYP3A5 phenotype in pediatric populations for subsequent correlations with the patient's genotype was investigated. Reversed-phase chromatography was performed using a Waters Alliance 2690 HPLC system. The synthesis of stable isotope labeled midazolam was carried out in seven steps. This assay will be particularly useful for examining the functional consequences of the variant and wild type CYP3A4 genotype.

本文言語English
ページ593-594
ページ数2
出版ステータスPublished - 2002 12 1
外部発表はい
イベントProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
継続期間: 2002 6 22002 6 6

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period02/6/202/6/6

ASJC Scopus subject areas

  • Spectroscopy

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