抄録
Cyclophilin B (CypB) possesses two antigenic epitopes (CypB84-92 and CypB91-99) recognized by HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes (CTLs). To determine the safety of CypB-derived peptides and its ability to generate antitumor immune responses, patients with advanced lung cancer received subcutaneous vaccinations of these peptides or their modified peptides. All 16 patients were vaccinated with CypB91-99 or its modified peptide, whereas only two patients were vaccinated with the modified CypB84-92, as immediate-type hypersensitivity to CypB84-92 or its modified peptide was observed in the remaining patients. No severe adverse events were associated with the vaccination. No significant increase in cellular responses to either peptides or tumor cells was observed in the postvaccination PBMCs by the conventional CTL assays in any patients tested. These results suggest that the vaccination of CypB91-99 peptide was safe, but failed to induce objective immune responses at this regimen.
本文言語 | English |
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ページ(範囲) | 439-444 |
ページ数 | 6 |
ジャーナル | Journal of Immunotherapy |
巻 | 25 |
号 | 5 |
DOI | |
出版ステータス | Published - 2002 1月 1 |
外部発表 | はい |
ASJC Scopus subject areas
- 免疫アレルギー学
- 免疫学
- 薬理学
- 癌研究