Pharmacology of N-type Ca2+ channels distributed in cardiovascular system (Review)

Hisayuki Uneyama, Akira Takahara, Minoru Wakamori, Yasuo Mori, Ryota Yoshimoto

研究成果: Article査読

19 被引用数 (Scopus)

抄録

Irregular functions in Ca2+ channels are intimately involved in many aspects of cardiovascular diseases. We can obtain a wide variety of L-type Ca2+ channel antagonists to treat hypertension and angina pectoris. Dihydropyridines (DHPs) have, first of all, been extensively developed due to their high selectivity for L-type Ca2+ channel and safety in pharmacological aspects. In contrast, many lines of evidence suggest that clinical efficacy of those DHPs are limited and undesirable effects are sometimes observed because of the specific distribution of L-type Ca2+ channels. As well as the L-type, peripherally distributed N-type Ca2+ channel plays a key role in cardiovascular regulation through autonomie nervous system. Recently, we developed a unique DHP derivative, cilnidipine (FRC8653) which has a dual antagonistic action on both L-type and N-type Ca2+ channels. Our recent studies with this DHP have made it clear that the N-type Ca2+ channel is also a new therapeutic target in cardiovascular diseases. We review the recent advances in pharmacology of the N-type Ca2+ channel and therapeutic implications of their antagonists.

本文言語English
ページ(範囲)455-466
ページ数12
ジャーナルInternational journal of molecular medicine
3
5
出版ステータスPublished - 1999 12月 1
外部発表はい

ASJC Scopus subject areas

  • 遺伝学

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