PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan

Takashi Kaneko, Tamaki Yano, Kamna Aggarwal, Jae Hong Lim, Kazunori Ueda, Yoshiteru Oshima, Camilla Peach, Deniz Erturk-Hasdemir, William E. Goldman, Byung Ha Oh, Shoichiro Kurata, Neal Silverman

研究成果: Article査読

260 被引用数 (Scopus)

抄録

Drosophila rely entirely on an innate immune response to combat microbial infection. Diaminopimelic acid-containing peptidoglycan, produced by Gram-negative bacteria, is recognized by two receptors, PGRP-LC and PGRP-LE, and activates a homolog of transcription factor NF-κB through the Imd signaling pathway. Here we show that full-length PGRP-LE acted as an intracellular receptor for monomeric peptidoglycan, whereas a version of PGRP-LE containing only the PGRP domain functioned extracellularly, like the mammalian CD14 molecule, to enhance PGRP-LC-mediated peptidoglycan recognition on the cell surface. Interaction with the imd signaling protein was not required for PGRP-LC signaling. Instead, PGRP-LC and PGRP-LE signaled through a receptor-interacting protein homotypic interaction motif-like motif. These data demonstrate that like mammals, drosophila use both extracellular and intracellular receptors, which have conserved signaling mechanisms, for innate immune recognition.

本文言語English
ページ(範囲)715-723
ページ数9
ジャーナルNature Immunology
7
7
DOI
出版ステータスPublished - 2006 7

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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