Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice

Yuki Takayanagi, Masahide Yoshida, Isadora F. Bielsky, Heather E. Ross, Masaki Kawamata, Tatsushi Onaka, Teruyuki Yanagisawa, Tadashi Kimura, Martin M. Matzuk, Larry J. Young, Katsuhiko Nishimori

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The oxytocin receptor (OXTR) and its ligand, oxytocin (OXT), regulate reproductive physiology (i.e., parturition and lactation) and sociosexual behaviors. To define the essential functions of OXTR, we generated mice with a null mutation in the Oxtr gene (Oxtr-/-) and compared them with OXT-deficient (Oxt-/-) mice. Oxtr-/- mice were viable and had no obvious deficits in fertility or reproductive behavior. Oxtr -/- dams exhibited normal parturition but demonstrated defects in lactation and maternal nurturing. Infant Oxtr-/- males emitted fewer ultrasonic vocalizations than wild-type littermates in response to social isolation. Adult Oxtr-/- males also showed deficits in social discrimination and elevated aggressive behavior. Ligand Oxt-/- males from Oxtr-/- dams, but not from Oxt+/- dams, showed similar high levels of aggression. These data suggest a developmental role for the OXT/OXTR system in shaping adult aggressive behavior. Our studies demonstrate that OXTR plays a critical role in regulating several aspects of social behavior and may have important implications for developmental psychiatric disorders characterized by deficits in social behavior.

元の言語English
ページ(範囲)16096-16101
ページ数6
ジャーナルProceedings of the National Academy of Sciences of the United States of America
102
発行部数44
DOI
出版物ステータスPublished - 2005 11 1

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    Takayanagi, Y., Yoshida, M., Bielsky, I. F., Ross, H. E., Kawamata, M., Onaka, T., Yanagisawa, T., Kimura, T., Matzuk, M. M., Young, L. J., & Nishimori, K. (2005). Pervasive social deficits, but normal parturition, in oxytocin receptor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 102(44), 16096-16101. https://doi.org/10.1073/pnas.0505312102