Personality-dependent dissociation of absolute and relative loss processing in orbitofrontal cortex

Juri Fujiwara, Philippe N. Tobler, Masato Taira, Toshio Iijima, Kenichiro Tsutsui

研究成果: Article査読

14 被引用数 (Scopus)


A negative outcome can have motivational and emotional consequences on its own (absolute loss) or in comparison to alternative, better, outcomes (relative loss). The consequences of incurring a loss are moderated by personality factors such as neuroticism and introversion. However, the neuronal basis of this moderation is unknown. Here we investigated the neuronal basis of loss processing and personality with functional magnetic resonance imaging in a choice task. We separated absolute and relative financial loss by sequentially revealing the chosen and unchosen outcomes. With increasing neuroticism, activity in the left lateral orbitofrontal cortex (OFC) preferentially reflected relative rather than absolute losses. Conversely, with increasing introversion, activity in the right lateral OFC preferentially reflected absolute rather than relative losses. These results suggest that personality affects loss-related processing through the lateral OFC, and propose a dissociation of personality dimension and loss type on the neuronal level.

ジャーナルEuropean Journal of Neuroscience
出版ステータスPublished - 2008 3月 1

ASJC Scopus subject areas

  • 神経科学(全般)


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