Perospirone augmentation of paroxetine in treatment of refractory obsessive-compulsive disorder with depression

Tatsui Otsuka, Takashi Togo, Naoya Sugiyama, Kumi Uehara, Asuka Yoshimi, Aya Karashima, Hiromi Shioya, Yoshio Hirayasu

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Obsessive-compulsive disorder (OCD) is often complicated by depression. We report on a patient with treatment-refractory OCD and treatment-refractory major depression who demonstrated a robust response to augmentation of paroxetine with perospirone. Perospirone is a second-generation antipsychotic agent with antagonist effects on both serotonin 5-HT2A and dopamine D2 receptors, as well as a unique agonist effects on serotonin 5-HT1A receptors. Future studies would be valuable to elucidate the utility of augmentation therapy of selective serotonin reuptake inhibitors with perospirone in the treatment of refractory OCD with depression.

本文言語English
ページ(範囲)564-566
ページ数3
ジャーナルProgress in Neuro-Psychopharmacology and Biological Psychiatry
31
2
DOI
出版ステータスPublished - 2007 3 30
外部発表はい

ASJC Scopus subject areas

  • Pharmacology
  • Biological Psychiatry

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