Perfusion culture through a vasculature constructed in a tumor spheroid

Yuji Nashimoto, Yukako Teraoka, Akiko Nakamasu, Sanshiro Hanada, Yuichiro Arima, Yu Suke Torisawa, Hidetoshi Kotera, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

研究成果: Conference contribution

抄録

We developed a microfluidic system for a perfusion culture of tumor spheroids utilizing engineered vasculatures. By the definition of the cellular interaction between fibroblast cells in a tumor spheroid and endothelial cells in microchannels, we successfully induced angiogenic sprouts from the microchannels, which anastomosed with the spheroid and formed perfusable vasculatures. We continuously supplied medium to the tumor spheroid through the vasculature and evaluated the effect of perfusion on the growth of the tumor spheroid. Our perfusion system greatly improved the cellular proliferation activity, mimicking the nutrition supply and evacuation of waste product through vasculatures surrounding tumors in vivo.

本文言語English
ホスト出版物のタイトル21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
出版社Chemical and Biological Microsystems Society
ページ1029-1030
ページ数2
ISBN(電子版)9780692941836
出版ステータスPublished - 2020
外部発表はい
イベント21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
継続期間: 2017 10月 222017 10月 26

出版物シリーズ

名前21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
国/地域United States
CitySavannah
Period17/10/2217/10/26

ASJC Scopus subject areas

  • 化学工学(その他)
  • バイオエンジニアリング

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