Peptide drug release behavior from biodegradable temperature-responsive injectable hydrogels exhibiting irreversible gelation

Kazuyuki Takata, Hiroki Takai, Yuta Yoshizaki, Takuya Nagata, Keisuke Kawahara, Yasuyuki Yoshida, Akinori Kuzuya, Yuichi Ohya

研究成果: Article査読

6 被引用数 (Scopus)

抄録

We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation (F(P1/D+PA40)) was observed compared with a reversible (physical gelation) IP formulation (F(P1)). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.

本文言語English
論文番号38
ジャーナルGels
3
4
DOI
出版ステータスPublished - 2017 12
外部発表はい

ASJC Scopus subject areas

  • バイオエンジニアリング
  • 生体材料
  • 有機化学
  • ポリマーおよびプラスチック

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