Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan

Takayuki Kogure, Yoshiyuki Ueno, Koji Fukushima, Futoshi Nagasaki, Yasuteru Kondo, Jun Inoue, Yasunori Matsuda, Eiji Kakazu, Takeshi Yamamoto, Hiroyoshi Onodera, Yutaka Miyazaki, Hiromasa Okamoto, Takehiro Akahane, Tomoo Kobayashi, Yutaka Mano, Takao Iwasaki, Motoyasu Ishii, Tooru Shimosegawa

研究成果: Article

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Aim: To evaluate the efficacy of pegylated interferon α-2b (peg-IFNα-2b) plus ribavirin (RBV) therapy in Japanese patients with chronic hepatitis C (CHC) genotype Ib and a high viral load. Methods: One hundred and twenty CHC patients (58.3% male) who received peg-IFNα-2b plus RBV therapy for 48 wk were enrolled. Sustained virological response (SVR) and clinical parameters were evaluated. Results: One hundred (83.3%) of 120 patients completed 48 wk of treatment. 53 patients (44.3%) achieved SVR. Early virological response (EVR) and end of treatment response (ETR) rates were 50% and 73.3%, respectively. The clinical parameters (SVR vs non-SVR) associated with SVR, ALT (108.4 IU/L vs 74.5 IU/L, P = 0.063), EVR (76.4% vs 16.4%, P < 0.0001), adherence to peg-IFN (≥ 80% of planned dose) at week 12 (48.1% vs 13.6%, P = 0.00036), adherence to peg-IFN at week 48 (54.7% vs 16.2%, P < 0.0001) and adherence to RBV at week 48 (56.1% vs 32.1%, P = 0.0102) were determined using univariate analysis, and EVR and adherence to peg-IFN at week 48 were determined using multivariate analysis. In the older patient group (> 56 years), SVR in females was significantly lower than that in males (17% vs 50%, P = 0.0262). EVR and adherence to Peg-IFN were demonstrated to be the main factors associated with SVR. Conclusion: Peg-IFNα-2b plus RBV combination therapy demonstrated good tolerability in Japanese patients with CHC and resulted in a SVR rate of 44.3%. Treatment of elderly female patients is still challenging and maintenance of adherence to peg-IFNα-2b is important in improving the SVR rate.

元の言語English
ページ(範囲)7225-7230
ページ数6
ジャーナルWorld Journal of Gastroenterology
14
発行部数47
DOI
出版物ステータスPublished - 2008 12 21

ASJC Scopus subject areas

  • Gastroenterology

フィンガープリント Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Kogure, T., Ueno, Y., Fukushima, K., Nagasaki, F., Kondo, Y., Inoue, J., Matsuda, Y., Kakazu, E., Yamamoto, T., Onodera, H., Miyazaki, Y., Okamoto, H., Akahane, T., Kobayashi, T., Mano, Y., Iwasaki, T., Ishii, M., & Shimosegawa, T. (2008). Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan. World Journal of Gastroenterology, 14(47), 7225-7230. https://doi.org/10.3748/wjg.14.7225