Peak expiratory flow variability adjusted by forced expiratory volume in one second is a good index for airway responsiveness in asthmatics

Kazuto Matsunaga, Masae Kanda, Atsushi Hayata, Satoru Yanagisawa, Tomohiro Ichikawa, Keiichiro Akamatsu, Akira Koarai, Tsunahiko Hirano, Hisatoshi Sugiura, Yoshiaki Minakata, Masakazu Ichinose

研究成果: Article

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Background: The lowest peak expiratory flow (PEF) over a week, expressed as a percentage of the highest PEF (Min%Max PEF) has been reported to be the index that most closely correlates with airway hyperresponsiveness (AHR) in asthmatics. However, both fluctuation of the airway caliber and airflow limitation are regarded as physiological properties of asthma closely related to AHR. An accurate index that shows the degree of AHR may be obtained by combining the index of airway lability with the parameters that represent airway caliber. Methods: Ninety-two steroid-naive and twenty-eight steroid-treated asthmatic patients were enrolled. Using the physiological parameters obtained from spirometry and PEF monitoring, we investigated, the indices which correlate accurately with airway responsiveness measured by the inhalation challenge test. Results: Although the methacholine threshold was related to all parameters that represent airway caliber and lability, Min%Max PEF had the strongest correlation with AHR. When Min%Max PEF was adjusted by the airway geometric factors, the normalization of Min%Max PEF with forced expiratory volume in one second as a percentage of the predicted value (%FEV1) improved the relationship between Min%Max PEF and AHR. Conclusions: Min%Max PEF adjusted by %FEV1 showed a good correlation with airway responsiveness measured by the inhalation challenge test, and may be useful as a convenient alternative index of AHR in asthmatic patients.

元の言語English
ページ(範囲)1107-1112
ページ数6
ジャーナルInternal Medicine
47
発行部数12
DOI
出版物ステータスPublished - 2008 11 24

ASJC Scopus subject areas

  • Internal Medicine

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