Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma

Shigemitsu Horie; Hayato Nishida; Toshihiko Sakurai; Osamu Ichiyanagi; Tomoyuki Kato; Makoto Yagi; Takanobu Kabasawa; Teigo Asai; Norihiko Tsuchiya

doi:10.1111/iju.13567

Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma

Shigemitsu Horie, Hayato Nishida, Toshihiko Sakurai, Osamu Ichiyanagi, Tomoyuki Kato, Makoto Yagi, Takanobu Kabasawa, Teigo Asai, Norihiko Tsuchiya

研究成果: Article › 査読

抄録

Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.

本文言語	English
ページ（範囲）	627-629
ページ数	3
ジャーナル	International Journal of Urology
巻	25
号	6
DOI	https://doi.org/10.1111/iju.13567
出版ステータス	Published - 2018 6月
外部発表	はい

ASJC Scopus subject areas

泌尿器学

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10.1111/iju.13567

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title = "Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma",

abstract = "Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.",

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doi = "10.1111/iju.13567",

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AU - Horie, Shigemitsu

AU - Nishida, Hayato

AU - Sakurai, Toshihiko

AU - Ichiyanagi, Osamu

AU - Kato, Tomoyuki

AU - Yagi, Makoto

AU - Kabasawa, Takanobu

AU - Asai, Teigo

AU - Tsuchiya, Norihiko

PY - 2018/6

Y1 - 2018/6

N2 - Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.

AB - Pazopanib was administered to a 44-year-old man with local recurrence of retroperitoneal liposarcoma. Computed tomography showed an intestinal edema, which gradually progressed 15 months after pazopanib administration although he had no clinical symptoms. Upper gastrointestinal endoscopy implicated marked edematous hypertrophy of the Kerkling's fold. Pathological findings showed crystal deposition and fat accumulation, without a malignant component. All these abnormal findings resolved after pazopanib discontinuation.

KW - intestinal edema

KW - liposarcoma

KW - mucosal crystallization

KW - pazopanib

KW - tyrosine kinase inhibitor

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Pazopanib-induced crystal deposition in intestinal mucosa in a patient with retroperitoneal liposarcoma

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