Pax6 controls the expression of Lewis x epitope in the embryonic forebrain by regulating α1,3-Fucosyltransferase IX expression

Yasushi Shimoda, Youichi Tajima, Taka Osanai, Asao Katsume, Michinori Kohara, Takashi Kudo, Hisashi Narimatsu, Noriko Takashima, Yasuo Ishii, Shun Nakamura, Noriko Osumi, Yutaka Sanai

研究成果: Article査読

35 被引用数 (Scopus)

抄録

Pax6 is a transcription factor involved in brain patterning and neurogenesis. Expression of Pax6 is specifically observed in the developing cerebral cortex, where Lewis x epitope that is thought to play important roles in cell interactions is colocalized. Here we examined whether Pax6 regulates localization of Lewis x using Pax6 mutant rat embryos. The Lewis x epitope disappeared in the Pax6 mutant cortex, and activity of α1,3-fucosyltransferase, which catalyzed the last step of Lewis x biosynthesis, drastically decreased in the mutant cortex as compared with the wild type. Furthermore, expression of a fucosyltransferase gene, FucT-IX, specifically decreased in the mutant, while no change was seen for expression of another fucosyltransferase gene, FucT-IV. These results strongly suggest that Pax6 controls Lewis x expression in the embryonic brain by regulating FucT-IX gene expression.

本文言語English
ページ(範囲)2033-2039
ページ数7
ジャーナルJournal of Biological Chemistry
277
3
DOI
出版ステータスPublished - 2002 1月 18
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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