Patient characteristics and effects of the long-acting calcium channel blocker barnidipine on circadian blood pressure changes: Results of the Japanese Multicenter Study on Barnidipine with Ambulatory Blood Pressure Monitoring

Kazuyuki Shimada, Yutaka Imai, Iwao Kuwajima, Keishi Abe

研究成果: Review article査読

5 被引用数 (Scopus)

抄録

The results of blood pressure variability patterns in the Japanese Multicenter Study on Barnidipine with Ambulatory Blood Pressure Monitoring (J-MUBA) were analyzed after evaluating daytime and night-time blood pressure levels in 502 hypertensive patients. The patients were divided into the high- (398 patients [79%]) and low-systolic blood pressure (SBP) groups based on 24-h SBP. Patients in the high-SBP group were further subdivided into four groups based on the nocturnal/daytime SBP ratio (nocturnal SBP reduction rate). The inverted dipper group consisted of 53 patients (13%), nondipper group of 116 patients (29%), dipper group of 166 patients (42%), and extreme dipper group of 63 patients (16%). After averaging 24-h SBP, it was found that age, female gender, and a prior history of stroke were independent predictors of inadequate nocturnal SBP reduction. Blood pressure variability patterns were evaluated in 387 hypertensive patients at baseline and after 6 months' administration of barnidipine. Although barnidipine decreased outpatient clinic blood pressure and had hypotensive effects over 24 h, it did not influence heart rate. When the effects of barnidipine on 24-h blood pressure were evaluated after classifying the 387 patients into high- and low-SBP groups, barnidipine adequately controlled blood pressure in the high-SBP group over 24 h, but had less effect on blood pressure in the low-SBP group. In addition, when the effects of barnidipine were evaluated in the high-SBP group based on blood pressure variability pattern, barnidipine similarly decreased daytime and night-time blood pressure in both the inverted dipper and non-dipper groups. However, barnidipine had only weak hypotensive effects in the dipper group during the night-time. In the extreme dipper group, although barnidipine markedly decreased elevated daytime blood pressure, it did not further lower night-time blood pressure.

本文言語English
ページ(範囲)S25-S30
ジャーナルBlood pressure monitoring
6
SUPPL. 2
出版ステータスPublished - 2001 12 1

ASJC Scopus subject areas

  • 内科学
  • 循環器および心血管医学
  • 評価と診断
  • 高度および特殊看護

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