Pathological study of subacute autoimmune encephalopathy with anti-AQP4 antibodies in a pregnant woman

Hiroaki Yaguchi, Ichiro Yabe, Yoshiki Takai, Tatsuro Misu, Masaaki Matsushima, Toshiyuki Takahashi, Kanako C. Kubota, Sachiko Akimoto, Kazuo Fujihara, Hidenao Sasaki

研究成果: Article査読

6 被引用数 (Scopus)

抄録

A pregnant woman with extensive brain lesions on magnetic resonance imaging was tested positive for anti-aquaporin4 (AQP4) antibodies. An open biopsy of the left temporal lobe showed pathological changes in both the white and gray matter. Hematoxylin and eosin, Klüver-Barrera, and myelin basic protein staining results were indicative of demyelination in the white matter. Loss of AQP4 and glial fibrillary acidic protein was observed in the white matter, and this finding is consistent with the neuropathological findings of neuromyelitis optica spinal lesions. Moreover, loss of AQP4 was observed in the gray matter. The presence of anti-AQP4 antibodies, and the pathology, led to the diagnosis of anti-AQP4 antibodies-related encephalopathy.

本文言語English
ページ(範囲)683-687
ページ数5
ジャーナルMultiple Sclerosis Journal
18
5
DOI
出版ステータスPublished - 2012 5月

ASJC Scopus subject areas

  • 神経学
  • 臨床神経学

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