Paramagnetic relaxation-based 19F MRI probe to detect protease activity

Shin Mizukami, Rika Takikawa, Fuminori Sugihara, Yuichiro Hori, Hidehito Tochio, Markus Wälchli, Masahiro Shirakawa, Kazuya Kikuchi

研究成果: Article査読

186 被引用数 (Scopus)

抄録

A novel design principle for 19F MRI probes detecting protease activity was developed. This principle is based on 19F MRI signal quenching by the intramolecular paramagnetic effect from Gd3+. The intramolecular Gd3+ dramatically attenuated the 19F probe signal, and the paramagnetic effect was cancelled by the probe hydrolyzation by caspase-3. Using this probe, it was shown that the probe could detect caspase-3 activity spatially from a phantom image using 19F MRI.

本文言語English
ページ(範囲)794-795
ページ数2
ジャーナルJournal of the American Chemical Society
130
3
DOI
出版ステータスPublished - 2008 1 23
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)
  • 生化学
  • コロイド化学および表面化学

フィンガープリント

「Paramagnetic relaxation-based <sup>19</sup>F MRI probe to detect protease activity」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル