Paradoxical progression of biliary strictures against recovery of biochemical parameters under ursodeoxycholic acid treatment in a case of primary sclerosing cholangitis with ulcerative colitis

Koga Komatsu, Tooru Shimosegawa, Satoru Kikuchi, Midori Uchi, Yoshisuke Maruhama, Norihiro Kisara, Yoshiyuki Ueno, Takayoshi Toyota

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Ursodeoxycholic acid (UDCA) treatment for primary sclerosing cholangitis (PSC) has been considered a rational therapy, though its effectiveness in the clinical course is still open to discussion. In this report, we describe a 22-year-old man with PSC at an early stage, which was associated with ulcerative colitis (UC). He showed progressive strictures of bile ducts over a 1.5-year period in spite of an improvement in the biochemical parameters by UDCA treatment. Therefore, care should be taken in interpreting the effectiveness of UDCA, because the biochemical parameters may not change in parallel with the clinical course of PSC.

本文言語English
ページ(範囲)1049-1053
ページ数5
ジャーナルInternal Medicine
39
12
DOI
出版ステータスPublished - 2000 12月

ASJC Scopus subject areas

  • 内科学

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