Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with hepatitis-associated aplastic anemia

Takehiko Mori, Yasushi Onishi, Yukiyasu Ozawa, Chiaki Kato, Tatsuyuki Kai, Yoshinobu Kanda, Mineo Kurokawa, Masatsugu Tanaka, Takashi Ashida, Yasushi Sawayama, Takahiro Fukuda, Tatsuo Ichinohe, Yoshiko Atsuta, Hirohito Yamazaki

研究成果: Article

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Outcomes of allogeneic hematopoietic stem cell transplantation (HSCT) for hepatitis-associated aplastic anemia have not been fully evaluated. In the present study, the outcomes of 37 adult patients with hepatitis-associated aplastic anemia who underwent allogeneic HSCT were retrospectively analyzed using the registry database of Japan Society for Hematopoietic Cell Transplantation. The median age of the patients was 24 years (range, 16–61). The median period between diagnosis of hepatitis-associated aplastic anemia and HSCT was 6.0 months (range, 0.5–430.8). Stem cell sources were bone marrow (N = 19) or peripheral blood stem cells (N = 5) from an HLA-identical sibling or bone marrow (N = 11) and cord blood (N = 2) from an unrelated donor. The majority of conditioning regimens were fludarabine-based or high-dose cyclophosphamide-based. In all but 2 cases of early death, neutrophil engraftment was achieved. At the time of analysis, 32 patients were alive, with a median follow-up of 54.1 months. Five-year overall and failure-free survival rates were 86.0% (95% CI, 69.4–93.9%) and 75.0% (95% CI, 57.4–86.2%), respectively. Despite the heterogeneity in transplant procedures in a small number of patients, these results suggest that allogeneic HSCT is safe for use in hepatitis-associated aplastic anemia with a low rate of transplant-related mortality.

元の言語English
ページ(範囲)711-717
ページ数7
ジャーナルInternational journal of hematology
109
発行部数6
DOI
出版物ステータスPublished - 2019 6 20

ASJC Scopus subject areas

  • Hematology

フィンガープリント Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with hepatitis-associated aplastic anemia' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Mori, T., Onishi, Y., Ozawa, Y., Kato, C., Kai, T., Kanda, Y., Kurokawa, M., Tanaka, M., Ashida, T., Sawayama, Y., Fukuda, T., Ichinohe, T., Atsuta, Y., & Yamazaki, H. (2019). Outcome of allogeneic hematopoietic stem cell transplantation in adult patients with hepatitis-associated aplastic anemia. International journal of hematology, 109(6), 711-717. https://doi.org/10.1007/s12185-019-02644-8