Ortho-C-H Acetoxylation of Cubane Enabling Access to Cubane Analogues of Pharmaceutically Relevant Scaffolds

Shota Nagasawa, Masaki Hosaka, Yoshiharu Iwabuchi

研究成果: Article査読

抄録

A novel method of introducing an oxygen functionality into a cubane core was developed using a transition-metal-catalyzed directed acetoxylation methodology via C-H activation. The obtained compounds were derivatized into cubane analogues of pharmaceutically relevant structural motifs, namely, acetylsalicylic acid and coumarin motifs, which could potentially act as bioisosteres of these scaffolds.

本文言語English
ページ(範囲)8717-8721
ページ数5
ジャーナルOrganic letters
23
22
DOI
出版ステータスPublished - 2021 11 19

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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