Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice

Akira Asai, Takahisa Nakano, Masahiro Takahashi, Akihiko Nagao

研究成果: Article査読

154 被引用数 (Scopus)

抄録

A series of crocetin glycosides (crocins) are the main pigment of the stigmas of saffron (Crocus sativus L.) and the fruits of gardenia (Gardenia jasminoides Ellis). Although numerous studies have demonstrated that crocetin and crocins have a variety of biological functions, the metabolism of dietary crocetin and crocins remains unknown. In the present study, we investigated the intestinal absorption of orally administered crocetin and crocins in mice. Orally administered crocetin was rapidly absorbed into the blood circulation and was present in plasma as an intact free form and as glucuronide conjugates (crocetin-monoglucuronide and -diglucuronide). Crocetin and its glucuronide conjugates were also found in crocins-administered mouse plasma, whereas intact crocins (glycoside forms) were not detected. These results indicate that orally administered crocins are hydrolyzed to crocetin before or during intestinal absorption, and absorbed crocetin is partly metabolized to mono- and diglucuronide conjugates.

本文言語English
ページ(範囲)7302-7306
ページ数5
ジャーナルJournal of Agricultural and Food Chemistry
53
18
DOI
出版ステータスPublished - 2005 9月 7
外部発表はい

ASJC Scopus subject areas

  • 化学 (全般)
  • 農業および生物科学(全般)

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