Optimum inspiratory conditions of targeting therapy of the upper airways for anti-influenza virus inhalers

Hiroshi Takano, Yuta Kitazato, Hideo Kusuzawa, Masayuki Itoh, Hidenori Murayama, Chiyohiko Shindoh

研究成果: Article査読

抄録

Anti-influenza virus inhalers formulated as a dry powder have been applied clinically in the treatment of seasonal influenza, which is one of the upper respiratory tract infections. In this study, the optimum respiratory conditions were examined together with the degrees of suitable drug delivery efficiency to the the local upper airways, because the degree of efficiency varied as functions of the particle size distributions of inhaled drugs and the respiratory conditions. Dry powder inhalers, such as zanamivir hydrate and laninamivir octanoate hydrate, were used in the experiments. From the experimental results in the measurement of the inhaled particle size distributions and the analysis of the degree of drug delivery efficiency, the optimum degree of respiratory effect based on the efficiency findings was adequately obtained in patients breathing normally in a sitting position.

本文言語English
ページ(範囲)49-55
ページ数7
ジャーナルOto-Rhino-Laryngology Tokyo
55
SUPPL. 1
出版ステータスPublished - 2012 8月

ASJC Scopus subject areas

  • 耳鼻咽喉科学

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