Opioid receptor antagonist nalmefene stereospecifically inhibits glutamate release during global cerebral ischemia

S. H. Graham, H. Shimizu, A. Newman, P. Weinstein, A. I. Faden

研究成果: Article査読

18 被引用数 (Scopus)

抄録

The opioid receptor antagonist nalmefene improves cellular bioenergetics and attenuates the reduction in tissue glutamate levels after global cerebral ischemia/reperfusion. The latter finding suggests that nalmefene might inhibit glutamate release during ischemia. To test this hypothesis, we used microdialysis techniques to examine the effect of nalmefene pretreatment on extracellular excitatory amino acid levels during global cerebral ischemia in rats. Saline, (-)-nalmefene (20, 100 or 500 μg/kg) or the inactive nalmefene enantiomer (+)-nalmefene (100 μg/kg) were given 15 min prior to induction of ischemia using a multi-vessel occlusion model. Pretreatment with (-)-nalmefene decreased peak dialysate glutamate in a dose-dependent fashion as compared to saline-treated controls, whereas (+)-nalmefene had no effect. These results suggest that opioid receptors may modulate glutamate release during ischemia and that inhibition of excitatory amino acid release may contribute to the protective actions of opioid receptor antagonists in cerebral ischemia.

本文言語English
ページ(範囲)346-350
ページ数5
ジャーナルBrain research
632
1-2
DOI
出版ステータスPublished - 1993 12月 31

ASJC Scopus subject areas

  • 神経科学(全般)
  • 分子生物学
  • 臨床神経学
  • 発生生物学

フィンガープリント

「Opioid receptor antagonist nalmefene stereospecifically inhibits glutamate release during global cerebral ischemia」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル