One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step

Yujiro Hayashi, Daisuke Sakamoto, Daichi Okamura

研究成果: Article査読

25 被引用数 (Scopus)

抄録

An efficient asymmetric total synthesis of (S)-baclofen was accomplished via a one-pot operation from commercially available materials using sequential reactions, such as aldol condensation of acetaldehyde, diphenylprolinol silyl ether mediated asymmetric Michael reaction of nitromethane, Kraus-Pinnick oxidation, and Raney Ni reduction. Highly enantioenriched baclofen was obtained in one pot with a good yield over four reactions.

本文言語English
ページ(範囲)4-7
ページ数4
ジャーナルOrganic letters
18
1
DOI
出版ステータスPublished - 2016 1 4

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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