One-pot high-yielding synthesis of the DPP4-selective inhibitor ABT-341 by a four-component coupling mediated by a diphenylprolinol silyl ether

Chemistry

• Silyl Ether 100%
• Michael Reaction 100%
• Amide 50%
• Reduction 50%
• Diastereoselectivity 50%
• Enantioselectivity 50%
• Reaction Yield 50%
• Asymmetry 50%
• Isomerization 50%
• Chemical Bond 50%
• Nitro Group 50%
• Chemical Reaction 50%
• Procedure 50%
• Synthesis (Chemical) 50%
• Base 50%
• Inhibitor 50%
• Aldol Reaction 50%