One-pot high-yielding synthesis of the DPP4-selective inhibitor ABT-341 by a four-component coupling mediated by a diphenylprolinol silyl ether

Hayato Ishikawa, Masakazu Honma, Yujiro Hayashi

研究成果: Article査読

105 被引用数 (Scopus)

抄録

A dream come true: ABT-341 was synthesized in high yield with excellent diastereo- and enantioselectivity in a one-pot process mediated by a diphenylprolinol silyl ether (see scheme; TMS=trimethylsilyl). Thus, an asymmetric Michael reaction, a domino Michael/Horner-Wadsworth-Emmons reaction combined with a retro-aldol reaction, base-catalyzed isomerization, amide-bond formation, and reduction of the nitro group all took place in a single flask.

本文言語English
ページ(範囲)2824-2827
ページ数4
ジャーナルAngewandte Chemie - International Edition
50
12
DOI
出版ステータスPublished - 2011 3月 14
外部発表はい

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

フィンガープリント

「One-pot high-yielding synthesis of the DPP4-selective inhibitor ABT-341 by a four-component coupling mediated by a diphenylprolinol silyl ether」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル