One-pot chemoenzymatic route to chitoheptaose via specific transglycosylation of chitopentaoseoxazoline on chitinase-template

Naoki Yoshida, Tomonari Tanaka, Masato Noguchi, Atsushi Kobayashi, Kumiko Ishikura, Tatsuya Ikenuma, Hiromu Seno, Takeshi Watanabe, Michinari Kohri, Shin Ichiro Shoda

研究成果: Article

14 引用 (Scopus)

抜粋

One-pot regio- and stereospecific synthesis of chitoheptaose ((GlcNAc) 7) has been achieved by using chitopentaose ((GlcNAc) 5) and chitobiose ((GlcNAc) 2) as starting materials. The key intermediate, 1,2-oxazoline derivative of (GlcNAc) 5, could be directly prepared in water and successfully transglycosylated to (GlcNAc) 2 catalyzed by a mutant chitinase with lower hydrolyzing activity.

元の言語English
ページ(範囲)689-690
ページ数2
ジャーナルChemistry Letters
41
発行部数7
DOI
出版物ステータスPublished - 2012 7 30

ASJC Scopus subject areas

  • Chemistry(all)

フィンガープリント One-pot chemoenzymatic route to chitoheptaose via specific transglycosylation of chitopentaoseoxazoline on chitinase-template' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Yoshida, N., Tanaka, T., Noguchi, M., Kobayashi, A., Ishikura, K., Ikenuma, T., Seno, H., Watanabe, T., Kohri, M., & Shoda, S. I. (2012). One-pot chemoenzymatic route to chitoheptaose via specific transglycosylation of chitopentaoseoxazoline on chitinase-template. Chemistry Letters, 41(7), 689-690. https://doi.org/10.1246/cl.2012.689