Oncogenic cell cycle start control

Shigeki Jinno, Jie Lin, Mika Yageta, Hiroto Okayama

研究成果: Review article査読

3 被引用数 (Scopus)

抄録

The ability to proliferate in the absence of anchorage is a fundamental attribute of cancer cells, yet how it is acquired is one central problem in cancer biology. By utilizing growth factor-transformable NRK cells and its insensitive mutants, we recently found that oncogenic stimulation invokes Cdk6 to participate in a critical step of the cell cycle start, but not via the regulation of its catalytic activity and that Cdk6 participation closely correlates with the anchorage-independent growth ability. Since many hematopoietic cells employ predominantly Cdk6 for the cell cycle start and perform anchorage-independent growth by nature, this finding raises the possibility that the mechanism by which oncogenic stimulation invokes anchorage-independent growth of NRK cells is similar to the one used for hematopoietic cell proliferation. We discuss this novel mechanism and its implication.

本文言語English
ページ(範囲)23-29
ページ数7
ジャーナルMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
477
1-2
DOI
出版ステータスPublished - 2001 6 2
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 遺伝学
  • 健康、毒物学および変異誘発

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