Oestrogen receptor α and β mRNA expression in human endometrium throughout the menstrual cycle

Sachiko Matsuzaki, Takao Fukaya, Takashi Suzuki, Takashi Murakami, Hironobu Sasano, Akira Yajima

研究成果: Article査読

134 被引用数 (Scopus)

抄録

We examined the localization of oestrogen receptor (ER) β mRNA in the human endometrium throughout the menstrual cycle using non-radioactive in- situ hybridization with Brigati-tailed oligonucleotides. The findings were compared with those of ERα in order to examine the possible biological significance of ERβ in the human endometrium. Both ERα and ERβ mRNA expression were detected in all major human uterine cell types, including glandular epithelial cells, stromal cells and smooth muscle cells of the uterine wall, at every menstrual cycle stage. However, ERα mRNA expression was more prominent than that of ERβ in all cell types throughout the menstrual cycle. In proliferative phase endometrium, ERα mRNA was expressed in both glandular epithelial and stromal cells, while ERβ mRNA was expressed predominantly in glandular epithelial cells. Although the same pattern was observed in the secretory phase, both the ERα and ERβ mRNA expression was relatively weaker. These results suggest that oestrogenic effects occur predominantly through ERα, but that ERβ may also play a role in the modulation of oestrogenic action, especially on glandular epithelial cells in the human endometrium throughout the menstrual cycle.

本文言語English
ページ(範囲)559-564
ページ数6
ジャーナルMolecular Human Reproduction
5
6
DOI
出版ステータスPublished - 1999 6

ASJC Scopus subject areas

  • 生殖医学
  • 胎生学
  • 分子生物学
  • 遺伝学
  • 産婦人科学
  • 発生生物学
  • 細胞生物学

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