Odor Representations in Olfactory Cortex: Distributed Rate Coding and Decorrelated Population Activity

Keiji Miura, Zachary F. Mainen, Naoshige Uchida

研究成果: Article

102 引用 (Scopus)

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How information encoded in neuronal spike trains is used to guide sensory decisions is a fundamental question. In olfaction, a single sniff is sufficient for fine odor discrimination but the neural representations on which olfactory decisions are based are unclear. Here, we recorded neural ensemble activity in the anterior piriform cortex (aPC) of rats performing an odor mixture categorization task. We show that odors evoke transient bursts locked to sniff onset and that odor identity can be better decoded using burst spike counts than by spike latencies or temporal patterns. Surprisingly, aPC ensembles also exhibited near-zero noise correlations during odor stimulation. Consequently, fewer than 100 aPC neurons provided sufficient information to account for behavioral speed and accuracy, suggesting that behavioral performance limits arise downstream of aPC. These findings demonstrate profound transformations in the dynamics of odor representations from the olfactory bulb to cortex and reveal likely substrates for odor-guided decisions.

元の言語English
ページ(範囲)1087-1098
ページ数12
ジャーナルNeuron
74
発行部数6
DOI
出版物ステータスPublished - 2012 6 21

ASJC Scopus subject areas

  • Neuroscience(all)

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