Octacalcium phosphate bone substitute materials: Comparison between properties of biomaterials and other calcium phosphate materials

Osamu Suzuki, Yukari Shiwaku, Ryo Hamai

研究成果: Review article査読

6 被引用数 (Scopus)

抄録

Octacalcium phosphate (OCP) is a material that can be converted to hydroxyapatite (HA) under physiological environments and is considered a mineral precursor to bone apatite crystals. The structure of OCP consists of apatite layers stacked alternately with hydrated layers, and closely resembles the structure of HA. The performance of OCP as a bone substitute differs from that of HA materials in terms of their osteoconductivity and biodegradability. OCP manifests a cellular phagocytic response through osteoclast-like cells similar to that exhibited by the biodegradable material β-tricalcium phosphate (β-TCP). The use of OCP for human cranial bone defects involves using its granule or composite form with one of the natural polymers, viz., the reconstituted collagen. This review article discusses the differences and similarities in these calcium phosphate (Ca-P)-based materials from the viewpoint of the structure and their material chemistry, and attempts to elucidate why Ca-P materials, particularly OCP, display unique osteoconductive property.

本文言語English
ページ(範囲)187-199
ページ数13
ジャーナルDental materials journal
39
2
DOI
出版ステータスPublished - 2020

ASJC Scopus subject areas

  • Ceramics and Composites
  • Dentistry(all)

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