Low pressure (LP) exhaust hoods are an important component of steam turbines. The aerodynamic loss of LP exhaust hoods is almost the same as those of the stator and rotor blading in LP steam turbines. Designing high performance LP exhaust hoods should lead further enhancement of steam turbine efficiency. This paper presents the results of exhaust hood computational fluid dynamics (CFD) analyses using last stage exit velocity distributions measured in a full-scale development steam turbine as the inlet boundary condition to improve the accuracy of the CFD analysis. One of the main difficulties in predicting the aerodynamic performance of the exhaust hoods is the unsteady boundary layer separation of exhaust hood diffusers. A highly accurate unsteady numerical analysis is introduced in order to simulate the diffuser flows in LP exhaust hoods. Compressible Navier- Stokes equations and mathematical models for non-equilibrium condensation are solved using the high-order high-resolution finite-difference method based on the fourth-order compact MUSCL TVD scheme, Roe's approximate Riemann solver, and the LU-SGS scheme. The SST turbulence model is also solved for evaluating the eddy viscosity. The computational results were validated using the measurement data, and the present CFD method was proven to be suitable as a useful tool for determining optimum three dimensional designs of LP turbine exhaust diffusers.