Nuclear factor-κB inhibitors as sensitizers to anticancer drugs

Chikashi Nakanishi, Masakazu Toi

研究成果: Review article査読

679 被引用数 (Scopus)

抄録

The cytotoxicity of chemotherapeutic agents is attributed to apoptosis. Acquired resistance to the effects of chemotherapy has emerged as a significant impediment to effective cancer therapy. One feature that cytotoxic treatments of cancer have in common is their activation of the transcription factor nuclear factor-κB (NF-κB), which regulates cell survival. NF-κB activation suppresses the apoptotic potential of chemotherapeutic agents and contributes to resistance. What evidence is there that inhibitors of NF-κB might promote apoptosis in cancer cells and can NF-κB inhibitors be used to overcome resistance to chemotherapeutic agents?

本文言語English
ページ(範囲)297-309
ページ数13
ジャーナルNature Reviews Cancer
5
4
DOI
出版ステータスPublished - 2005 4月

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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