Novel synthetic antimicrobial peptides effective against methicillin-resistant Staphylococcus aureus

J. Alvarez-Bravo, S. Kurata, S. Natori

研究成果: Article査読

60 被引用数 (Scopus)

抄録

Previously, we identified a core undecapeptide of sapecin B having antimicrobial activity. Based on the structure of this peptide, we systematically synthesized peptides consisting of terminal basic motifs and internal oligo-leucine sequences and examined their antimicrobial activities. Of these peptides, RLKLLLLLRLK-NH2 and KLKLLLLLKLK-NH2 were found to have potent microbicidal activity against Staphylococcus aureus, Escherichia coli, methicillin-resistant S. aureus and Candida albicans in liquid medium. We also synthesized the D-enantiomer of KLKLLLLLKLK-NH2. This enantiomer was resistant to tryptic digestion and persisted longer in the culture medium, showing greater antimicrobial activity than the original peptide.

本文言語English
ページ(範囲)535-538
ページ数4
ジャーナルBiochemical Journal
302
2
DOI
出版ステータスPublished - 1994
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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