Novel rat model of stress urinary incontinence with a retroflexed bladder

Naoki Kawamorita, Yasuhiro Kaiho, Haruo Nakagawa, Minoru Miyazato, Mabumi Matsushita, Yoichi Arai

研究成果: Article査読

3 被引用数 (Scopus)


Introduction and hypothesis: We created a rat model with a retroflexed bladder that mimicked the loss of the posterior urethrovesical angle and compared the results with sham-surgery rats for the establishment of rat models of stress urinary incontinence. Methods: The retroflexed bladder was created by stitching the bladder posteriorly to the psoas muscle. Sneeze-induced urethral pressure response and urethral baseline pressure were measured using a microtip-transducer catheter and leak point pressures induced by sneezing, the Crede maneuver, and the vertical tilt table method were measured via a supra-pubic cystostomy. Results: In rats with a retroflexed bladder, both urethral pressure response and sneeze-induced leak point pressure were significantly decreased. Conclusion: A retroflexed bladder may cause stress urinary incontinence by attenuating the sneeze-induced active urethral closure mechanism. Urethral pressure response restored by resumption of the posterior urethrovesical angle would explain why no sling tension is needed to treat the stress urinary incontinence.

ジャーナルInternational Urogynecology Journal
出版ステータスPublished - 2010 5

ASJC Scopus subject areas

  • 産婦人科学
  • 泌尿器学


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