Novel modulators for body weight changes induced by fasting and re-feeding in mice

Katsunori Nonogaki, Yukie Ohba, Makiko Sumii, Mamoru Wakameda, Tomohiro Tamari

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Catch-up weight gain after malnutrition is a risk factor for metabolic syndrome. Here we show that social isolation enhanced fasting-induced weight loss and suppressed weight gain induced by re-feeding for 6 days following a 24-h fast in prepubertal wild-type mice. These effects of social isolation on weight gain were not associated with significant changes in daily average food consumption. Under the same housing condition, genetic deletion of β-endorphin reduced the fasting-induced weight loss and enhanced the re-feeding-induced weight gain in prepubertal mice. These effects of social isolation or genetic deletion of β-endorphin on these weight changes were attenuated and reversed in postpubertal mice. Moreover, genetic deletion of β-endorphin attenuated these effects of social isolation on the catch-up weight gain in prepubertal mice and reversed them in postpubertal mice. Thus, social isolation, endogenous β-endorphin, and age can be novel modulators for body weight changes induced by fasting and re-feeding in mice.

本文言語English
ページ(範囲)249-254
ページ数6
ジャーナルBiochemical and biophysical research communications
378
2
DOI
出版ステータスPublished - 2009 1 9

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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