Novel insights into human respiratory syncytial virus-host factor interactions through integrated proteomics and transcriptomics analysis

研究成果: Review article査読

19 被引用数 (Scopus)

抄録

The lack of vaccine and limited antiviral options against respiratory syncytial virus (RSV) highlights the need for novel therapeutic strategies. One alternative is to develop drugs that target host factors required for viral replication. Several microarray and proteomics studies had been published to identify possible host factors that are affected during RSV replication. In order to obtain a comprehensive understanding of RSV-host interaction, we integrated available proteome and transcriptome datasets and used it to construct a virus-host interaction network. Then, we interrogated the network to identify host factors that are targeted by the virus and we searched for drugs from the DrugBank database that interact with these host factors, which may have potential applications in repositioning for future treatment options of RSV infection.

本文言語English
ページ(範囲)285-297
ページ数13
ジャーナルExpert Review of Anti-Infective Therapy
14
3
DOI
出版ステータスPublished - 2016 3 3

ASJC Scopus subject areas

  • 微生物学
  • 微生物学(医療)
  • ウイルス学
  • 感染症

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