Novel functions of complex carbohydrates elucidated by the mutant mice of glycosyltransferase genes

Koichi Furukawa, Kogo Takamiya, Masahiko Okada, Masahiro Inoue, Satoshi Fukumoto, Keiko Furukawa

研究成果: Review article査読

63 被引用数 (Scopus)

抄録

Complex carbohydrates consist of carbohydrate moieties and protein or lipid portions, resulting in the formation of glycoproteins, proteoglycans or glycosphingolipids. The polymorphic carbohydrate structures are believed to contain profound biological implications which are important in cell-cell or cell-extracellular matrix interactions. A number of studies to delineate the roles of carbohydrates have been performed, and demonstrated definite changes in their profiles, cellular phenotypic changes or, sometimes, morphological and functional changes in tissues after modification of their structures. Recent successes in the isolation of glycosyltransferase genes and their modification enzyme genes has enabled clearer demonstrations of the roles of complex carbohydrates. In particular, genetic modification of glycosyltransferase genes in mice can elucidate the biological significances of their products in vivo. Here, we summarize recent advances in the understanding of the roles of complex carbohydrates provided from studies of gene knock-out mice of glycosyltransferase and modification enzyme genes focusing on novel functions which had not been expected.

本文言語English
ページ(範囲)1-12
ページ数12
ジャーナルBiochimica et Biophysica Acta - General Subjects
1525
1-2
DOI
出版ステータスPublished - 2001 2 16
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学

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