Novel cyclic peptide, epichlicin, from the endophytic fungus, Epichloe typhina

Yoshiya Seto, Kosaku Takahashi, Hideyuki Matsuura, Yasunori Kogami, Hiroshi Yada, Teruhiko Yoshihara, Kensuke Nabeta

    研究成果: Article査読

    33 被引用数 (Scopus)

    抄録

    The novel cyclic peptide, epichlicin, was isolated from Epichloe typhina, an endophytic fungus of the timothy plant (Phleum pretense L.). Its structure was determined by NMR studies and by mass spectrometry. Enantiomers of 3-amino tetradecanoic acid, a constituent amino acid of epichlicin, were synthesized as authentic standards. The stereochemistry of each amino acid was elucidated through a combination of the advanced Marfey method and chemical manipulation. Epichlicin showed inhibitory activity toward the spore germination of Cladosporium phlei, a pathogenic fungus of the timothy plant at an IC 50 value of 22 nM.

    本文言語English
    ページ(範囲)1470-1475
    ページ数6
    ジャーナルBioscience, Biotechnology and Biochemistry
    71
    6
    DOI
    出版ステータスPublished - 2007

    ASJC Scopus subject areas

    • バイオテクノロジー
    • 分析化学
    • 生化学
    • 応用微生物学とバイオテクノロジー
    • 分子生物学
    • 有機化学

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