Nonthrombogenic, stretchable, active multielectrode array for electroanatomical mapping

Wonryung Lee, Shingo Kobayashi, Masase Nagase, Yasutoshi Jimbo, Itsuro Saito, Yusuke Inoue, Tomoyuki Yambe, Masaki Sekino, George G. Malliaras, Tomoyuki Yokota, Masaru Tanaka, Takao Someya

研究成果: Article査読

69 被引用数 (Scopus)


High-precision monitoring of electrophysiological signals with high spatial and temporal resolutions is one of the most important subjects for elucidating physiology functions. Recently, ultraflexible multielectrode arrays (MEAs) have been fabricated to establish conformal contacts with the surface of organs and to measure propagation of electrophysiological signals with high spatial-temporal resolution; however, plastic substrates have high Young's modulus, causing difficulties in creating appropriate stretchability and blood compatibility for applying them on the dynamically moving and surgical bleeding surface of the heart. Here, we have successfully fabricated an active MEA that simultaneously achieves nonthrombogenicity, stretchability, and stability, which allows long-term electrocardiographic (ECG) monitoring of the dynamically moving hearts of rats even with capillary bleeding. Because of the active data readout, the measured ECG signals exhibit a high signal-to-noise ratio of 52 dB. The novel stretchable MEA is carefully designed using state-of-the-art engineering techniques by combining extraordinarily high gain organic electrochemical transistors processed on microgrid substrates and a coating of poly(3-methoxypropyl acrylate), which exhibits significant antithrombotic properties while maintaining excellent ionic conductivity.

ジャーナルScience Advances
出版ステータスPublished - 2018 10 19

ASJC Scopus subject areas

  • 一般


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