Non-invasive imaging of radiocesium dynamics in a living animal using a positron-emitting 127Cs tracer

Nobuo Suzui, Takuya Shibata, Yong Gen Yin, Yoshihito Funaki, Keisuke Kurita, Hiroyuki Hoshina, Mitsutaka Yamaguchi, Shu Fujimaki, Noriaki Seko, Hiroshi Watabe, Naoki Kawachi

研究成果: Article査読

抄録

Visualizing the dynamics of cesium (Cs) is desirable to understand the impact of radiocesium when accidentally ingested or inhaled by humans. However, visualization of radiocesium in vivo is currently limited to plants. Herein, we describe a method for the production and purification of 127Cs and its use in visualizing Cs dynamics in a living animal. The positron-emitting nuclide 127Cs was produced using the 127I (α, 4n) 127Cs reaction, which was induced by irradiation of sodium iodide with a 4He2+ beam from a cyclotron. We excluded sodium ions by using a material that specifically adsorbs Cs as a purification column and successfully eluted 127Cs by flowing a solution of ammonium sulfate into the column. We injected the purified 127Cs tracer solution into living rats and the dynamics of Cs were visualized using positron emission tomography; the distributional images showed the same tendency as the results of previous studies using disruptive methods. Thus, this method is useful for the non-invasive investigation of radiocesium in a living animal.

本文言語English
論文番号16155
ジャーナルScientific reports
10
1
DOI
出版ステータスPublished - 2020 12 1

ASJC Scopus subject areas

  • General

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