Non-invasive blood glucose measurement using fixed-wavelength quantum cascade lasers

T. Koyama, S. Kino, Y. Matsuura

研究成果: Conference contribution

5 被引用数 (Scopus)

抄録

An ATR measurement system composed of hollow optical fibers, a trapezoid multi-reflection prism, and a couple of fixed-wavelength QCLs emitting different wavelengths is proposed for non-invasive measurement of blood glucose. To choose a wavelength combination that is appropriate for measurement of glucose absorption, firstly absorption spectra of human lip mucosa measured by using an FT-IR-based ATR system are investigated. As a result, two wavelengths, 1152 cm-1 that coincides with an absorption peak of glucose, and 1186 cm-1 where the glucose absorption becomes minimum are chosen. From numerical simulation using spectral absorptions measured by the FT-IR system, it is found that the differential absorption between the above wavelengths shows a good correlation to blood glucose levels. Finally in-vivo measurement using the ATR system equipped with two single-wavelength QCLs is performed and it is found that the measured optical absorption follows the blood glucose well.

本文言語English
ホスト出版物のタイトルOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX
編集者Israel Gannot, Israel Gannot
出版社SPIE
ISBN(電子版)9781510623866
DOI
出版ステータスPublished - 2019 1月 1
イベントOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX 2019 - San Francisco, United States
継続期間: 2019 2月 22019 2月 3

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
10872
ISSN(印刷版)1605-7422

Conference

ConferenceOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XIX 2019
国/地域United States
CitySan Francisco
Period19/2/219/2/3

ASJC Scopus subject areas

  • 電子材料、光学材料、および磁性材料
  • 原子分子物理学および光学
  • 生体材料
  • 放射線学、核医学およびイメージング

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