Nitrile Synthesis by Aerobic Oxidation of Primary Amines and in situ Generated Imines from Aldehydes and Ammonium Salt with Grubbs Catalyst

Tatsuki Utsumi, Kenta Noda, Daichi Kawauchi, Hirofumi Ueda, Hidetoshi Tokuyama

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Herein, a Grubbs-catalyzed route for the synthesis of nitriles via the aerobic oxidation of primary amines is reported. This reaction accommodates a variety of substrates, including simple primary amines, sterically hindered β,β-disubstituted amines, allylamine, benzylamines, and α-amino esters. Reaction compatibility with various functionalities is also noted, particularly with alkenes, alkynes, halogens, esters, silyl ethers, and free hydroxyl groups. The nitriles were also synthesized via the oxidation of imines generated from aldehydes and NH4OAc in situ. (Figure presented.).

本文言語English
ページ(範囲)3583-3588
ページ数6
ジャーナルAdvanced Synthesis and Catalysis
362
17
DOI
出版ステータスPublished - 2020 9 8

ASJC Scopus subject areas

  • 触媒
  • 有機化学

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