Nicotine infusion into rat ventromedial nuclei and effect on monoaminergic system

Eduardo J.B. Ramos, Michael M. Meguid, Lihua Zhang, Go Miyata, Serguei O. Fetissov, Chung Chen, Susumu Suzuki, Alessandro Laviano

研究成果: Article査読

14 被引用数 (Scopus)

抄録

Nicotine increases satiety and reduces food intake (Fl). We hypothesize that nicotine influences Fl via alteration of serotonin (5HT) and dopamine (DA) concentration in ventromedial nucleus (VMN) and lateral hypothalamic area (LHA). Microdialysis cannulas were implanted into ipsilateral VMN and contralateral LHA. Nicotine or vehicle was infused for 60 min into VMN of overnight food-deprived rats, followed by ad lib food for 40 min. Hypothalamic changes in 5HT and DA concentrations were measured every 20 min. Intra-VMN nicotine induced a long-lasting increase in 5HT concentration and an increase in DA for a short duration in the VMN, associated with an increase in 5HT in the LHA. Our data suggest that the nicotine-induced hypophagia correlates with VMN and LHA monoaminergic changes.

本文言語English
ページ(範囲)2293-2297
ページ数5
ジャーナルNeuroReport
15
14
DOI
出版ステータスPublished - 2004 10 5

ASJC Scopus subject areas

  • 神経科学(全般)

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