Nicotine imptoves cognitive disturbance in senescence-accelerated mice

K. Meguro, S. Yamaguchi, H. Arai, T. Nakagawa, C. Doi, M. Yamada, Y. Ikarashi, Y. Maruyama, H. Sasaki

研究成果: Article査読

22 被引用数 (Scopus)

抄録

Senescence-accelerated mice (SAM), a murine model of age-related deterioration in learning ability, were studied as to the acetylcholine (ACh) contents in the brain tissues and the effect of nicotine administration. We found that the ACh content of SAM-P/8 (accelerated senescence-prone) mice was lower than that of SAM-R/1 (accelerated senescence-resistant) mice in the midbrain thalamus and the hypothalamus. In addition, an IP administration of nicotine was found to improve learning ability of SAM-P/8 as shown by performance of a passive avoidance task. Nicotine may potentiate cognitive function in SAM-P/8.

本文言語English
ページ(範囲)769-772
ページ数4
ジャーナルPharmacology, Biochemistry and Behavior
49
3
DOI
出版ステータスPublished - 1994 11

ASJC Scopus subject areas

  • 生化学
  • 毒物学
  • 薬理学
  • 臨床生化学
  • 生物学的精神医学
  • 行動神経科学

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