New polyketides, paralactonic acids A–E produced by Paraconiothyrium sp. SW-B-1, an endophytic fungus associated with a seaweed, Chondrus ocellatus Holmes

Takuma Suzuki, Nanang Rudianto Ariefta, Takuya Koseki, Hiroshi Furuno, Eunsang Kwon, Hiroyuki Momma, Desi Harneti, Rani Maharani, Unang Supratman, Ken ichi Kimura, Yoshihito Shiono

研究成果: Article

6 被引用数 (Scopus)

抄録

Five polyketides, paralactonic acids A-E (1–5) were isolated from Paraconiothyrium sp. SW-B-1, an endophytic fungus isolated from the seaweed, Chondrus ocellatus Holmes. Their structures were determined by various spectroscopic methods, predominantly by 2D NMR spectroscopic analyses. The absolute configurations of compounds 1–5 were determined by comparison of the experimental and calculated ECD spectra. Compound 5 showed moderate antibacterial activity and restored the growth of a mutant yeast strain inhibited by hyperactivated Ca2+-signaling.

本文言語English
ページ(範囲)75-81
ページ数7
ジャーナルFitoterapia
132
DOI
出版ステータスPublished - 2019 1

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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