New multidrug resistance modulators from Atractylodis Lanceae Rhizoma

Nobutoshi Murakami, Etsuko Iwata, Satoru Tamura, Shin ichi Akiyama, Motomasa Kobayashi

研究成果: Article査読

10 被引用数 (Scopus)

抄録

Three new oligoacylated sucroses designated atractysucroses-I, -II, and -III were obtained from Atractylodis Lanceae Rhizoma as multidrug resistance (MDR) modulating substances against human carcinoma cell lines and their chemical structures were characterized as a mixture of acyl groups. Atractysucrose-I modulates MDR in KB-C2 cells as strongly as verapamil. This is the first example of an MDR-modulator classified as a carbohydrate. (C) 2000 Elsevier Science Ltd.

本文言語English
ページ(範囲)2629-2632
ページ数4
ジャーナルBioorganic and Medicinal Chemistry Letters
10
23
DOI
出版ステータスPublished - 2000 12 4

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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