New horizon of mucosal immunity and vaccines

Ichiro Takahashi, Tomonori Nochi, Yoshikazu Yuki, Hiroshi Kiyono

研究成果: Review article査読

50 被引用数 (Scopus)

抄録

Progress in the past quarter-century on understanding the molecular, cellular, and in vivo components of the mucosal immune system have allowed us to develop a practical strategy for a novel mucosal vaccine. The mucosal immune system can induce secretory IgA (SIgA) and serum IgG responses to provide two layers of defense against mucosal pathogens. For SIgA-mediated immunity in the gastrointestinal tract, the gut-associated lymphoid tissue contains both the tissue-dependent and tissue-independent IgA components. Harnessing the mucosal immune system for vaccine development may help prevent the global health problems caused by enteric infectious diseases. We have therefore combined mucosal immunology and plant biology to create a rice-based mucosal vaccine that requires neither needles and syringes nor refrigeration.

本文言語English
ページ(範囲)352-358
ページ数7
ジャーナルCurrent Opinion in Immunology
21
3
DOI
出版ステータスPublished - 2009 6
外部発表はい

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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