New diterpene pyrone-type compounds, metarhizins A and B, isolated from entomopathogenic fungus, Metarhizium flavoviride and their inhibitory effects on cellular proliferation

Haruhisa Kikuchi, Tomoko Hoshi, Minoru Kitayama, Mizuki Sekiya, Yasuhiro Katou, Kazunori Ueda, Yuzuru Kubohara, Hiroki Sato, Mitsuaki Shimazu, Shoichiro Kurata, Yoshiteru Oshima

研究成果: Article査読

28 被引用数 (Scopus)

抄録

To date, entomopathogenic fungi have not been extensively examined by natural product chemists. In this study, we isolated novel pyrone diterpene-type compounds, metarhizins A (1) and B (2), from methanol extracts of entomopathogenic fungus, Metarhizium flavoviride. They showed potent and selective antiproliferative activity against both insect and human cancer cell lines. These results indicate that metarhizins A (1) and B (2) can be used as novel lead compounds for anti-cancer agents and probes for cell cycle regulation. To further investigate the structural requirements for this inhibitory activity, we synthesized many metarhizin derivatives and evaluated their antiproliferative activities.

本文言語English
ページ(範囲)469-477
ページ数9
ジャーナルTetrahedron
65
2
DOI
出版ステータスPublished - 2009 1月 10

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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