@article{3762d1b8fa9b4bc3aabf6a657eba564f,
title = "New dimeric and monomeric chromanones, gonytolides D-G, isolated from the fungus Gonytrichum sp.",
abstract = "In the course of the screening of innate immune regulators from natural resources, we isolated new dimeric and monomeric chromanones, gonytolides D-G (4-7), from Gonytrichum sp. along with a known innate immune promoter, gonytolide A (1). The structures of these compounds were determined by spectral analysis, chemical conversion, and biogenetic consideration. The compounds 4-7 were evaluated on the innate immune response, indicating that the 8,8′-linked bischromanone rings were crucial for innate immune-promoting activity.",
keywords = "Bischromanone, Gonytrichum sp., Innate immunity, Tetrahydroxanthone",
author = "Haruhisa Kikuchi and Masato Isobe and Shoichiro Kurata and Yasuhiro Katou and Yoshiteru Oshima",
note = "Funding Information: We are grateful to the Bloomington Stock Center, Drosophila Genetic Resource Center at the Kyoto Institute of Technology, and the Genetic Strain Research Center of the National Institute of Genetics for the fly stocks. This work was supported in part by a Grant-in-Aid for Scientific Research (No. 21249004 , 21117005 , 21310134 , 21117005 , 21710215 and 23710247 ) from the Ministry of Education, Science, Sports and Culture of Japan ; Intelligent Cosmos Academic Foundation; A-STEP (FS-stage) (No. AS231Z03915G ) from Japan Science and Technology Agency ; the SUNBOR GRANT from the Suntory Institute for Bioorganic Research ; the Mitsubishi Foundation ; the Takeda Science Foundation ; Astellas Foundation for Research on Metabolic Disorders ; the Uehara Memorial Foundation ; the Naito Foundation ; and Program for Promotion of Basic Research Activities for Innovative BioSciences . ",
year = "2012",
month = aug,
day = "5",
doi = "10.1016/j.tet.2012.05.064",
language = "English",
volume = "68",
pages = "6218--6223",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "31",
}